Our previous work revealed that epileptiform discharges in children with epilepsy decrease during and right after listening to Mozart K.448. Mozart K.448 is a potential add-on therapy in children with refractory epilepsy. Epilepsy is a common pediatric neurologic disease in Thailand. Researchers at Kaohsiung Medical University and other centers in Taiwan studied the long-term effect of listening to Mozart K-448 (Sonata for Two Pianos in D major) on the frequency of epileptiform discharges in children with epilepsy, and analyzed the relationship between the number of epileptiform discharges and foci of origin, epilepsy etiology, age, IQ, and gender. Lin LC, Lee WT, Wang CH, Chen HL, Wu HC, Tsai CL, Wei RC, Mok HK, Weng CF, Lee MW, Yang RC. Epilepsy is a common pediatric neurologic disease in Thailand. found that the epileptiform discharges decrease during listening to Mozart K.448 in 23 of 29 patients with epilepsy .
et al.Mozart K.448 acts as a potential add-on therapy in children with refractory epilepsy. 2010; 89 (2–3):238–245.

Author information: (1)Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan.

Case number was limited; further study is needed to verify therapeutic implications. Mozart K.448 is a potential add-on therapy in children with refractory epilepsy. In the study, Dr Rafiee and colleagues asked 13 epilepsy patients to spend three months listening daily to Mozart’s 'Sonata for Two Pianos in D Major, K. 448'. However, the mainstay antiepileptic pharmacotherapies can induce severe side effects. Researchers at Kaohsiung Medical University and other centers in Taiwan studied the long-term effect of listening to Mozart K-448 (Sonata for Two Pianos in D major) on the frequency of epileptiform discharges in children with epilepsy, and analyzed the relationship between the number of epileptiform discharges and foci of origin, epilepsy etiology, age, IQ, and gender. "Our results showed daily listening to the first movement of Mozart K.448 was associated with reducing seizure frequency in adult individuals with epilepsy," says Dr. Rafiee. Over 70% of children with refractory epilepsy had a ≥50% reduction in seizure frequencies after at least 6 months of Mozart K.448 listening once per night .

Case number was limited; further study is needed to verify therapeutic implications. Mozart K.448 acts as a potential add-on therapy in children with refractory epilepsy. A continuous electroencephalogram was recorded before, during and after exposure to Mozart's Sonata for two pianos in D major, K.448 (piano K.448), and the frequencies of discharges were compared. Mentality, etiology, and gender did not affect the seizure reduction results. Mentality, etiology, and gender did not affect the seizure reduction results. "Our results showed daily listening to the first movement of Mozart K.448 was associated with reducing seizure frequency in adult individuals with epilepsy," says Dr. Rafiee. We conclude that Mozart K.448 should be further studied as a potential add-on therapy in the treatment of children with refractory epilepsy. Mozart's Sonata for Two Pianos in D major, K.448 (Mozart K.448), has been shown to improve mental function, leading to what is known as the Mozart Effect. However, the duration of the effect was not studied. Epilepsy Behav. Epilepsy Res. Mozart K.448 and epileptiform discharges: effect of ratio of lower to higher harmonics. Epilepsy Behav, 20(3):490-493, 02 Feb 2011 Cited by: 22 articles | PMID: 21292560 W… Lin LC(1), Lee WT, Wu HC, Tsai CL, Wei RC, Mok HK, Weng CF, Lee MW, Yang RC. Hughes et al.

"This suggests that daily Mozart listening may be considered as a supplemental therapeutic option to reduce seizures in individuals with epilepsy." W… "This suggests that daily Mozart listening may be considered as a supplemental therapeutic option to reduce seizures in individuals with epilepsy."
In the study, Dr Rafiee and colleagues asked 13 epilepsy patients to spend three months listening daily to Mozart’s 'Sonata for Two Pianos in D Major, K. 448'. "Our results showed daily listening to the first movement of Mozart K.448 was associated with reducing seizure frequency in adult individuals with epilepsy," says Dr. Rafiee. The long-term effect of listening to Mozart K.448 decreases epileptiform discharges in children with epilepsy.

[Google Scholar] Lin LC, Lee WT, Wang CH, Chen HL, Wu HC, Tsai CL, Wei RC, Mok HK, Weng CF, Lee MW. However, the mainstay antiepileptic pharmacotherapies can induce severe side effects. "Our results showed daily listening to the first movement of Mozart K.448 was associated with reducing seizure frequency in adult individuals with epilepsy," says Dr. Rafiee.