there is also a .17 mach 2 round that is a .22 LR round with a .17 high quality bullet.

Fired from a handgun or an actual rifle?

According to the book "Stopping Power, a Practical Analysis of the Latest Handgun Ammunition," by Evan Marshall and Ed Sanow, Head is right.

There's a small shop somewhere, where the magic happens (I have a feeling the shop is under wraps, due to high demand), with a legendary gunsmith to perform the conversion process. Given that, I think its pretty clear the .22WMR is more powerful than the .22LR. This is a cartridge with ballistic characteristics not so far from those of the .22 Magnum.

The 9mm, on the other hand, was specifically designed as a combat cartridge. The high-velocity rounds (which typically get around 120-140 ft-lbs of muzzle energy) are the next most powerful. Centerfire ammo is quite expensive. The most powerful .22LR rounds are the hyper-velocity rounds.

you simply cant put more in there. Is a .22LR powerful enough to cycle the massive slide on a Desert Beag... Eagle?

A .25-caliber air rifle is going to be less powerful than a .22LR.

Its just a tiny case that doesnt hold much is all..

Most Powerful 22LR Ammunition. Don’t be distracted by a comparison of steel vs brass casing ammo. The feed system is designed around a particular cartridge length. While a rimfire has an effective range of 100 yards, centerfire rifles do well beyond that. Powerful compared to what? Does that confuse you enough, or should I keep going? Most commonly, the bullet weight for 22LR ammo is 40 grains or below. You’ll have to shed $20 for just 50 rounds. Looking for the Most Powerful 22LR Ammo This is the fastest .22 LR. In forms ranging from small youth rifles, to full size replicas of modern military arms, survival, target shooting, military training, recreational shooting, and even self defense, the .22lr rifle has earned a …

I have some small varmints hanging around the house and since 22 ammo is relatively cheap so I decided to pick up the little Winchester. 22LR for Self Defense?

The .22LR tops out at 204 fpe in its hottest loading (the Aquila Supermax), with the average .22LR high-speed ammo delivering 120-140 fpe. 22LR ammo is arranged neatly and orderly in its box, giving you easy access for removal.

These are the great little hunting rounds with higher velocity and hollow points. The .17hmr travels round 2500fps vs 1200fps for the .22 LR. A .25 ACP from a pistol-length barrel will have less power than a high velocity .22LR from a rifle-length barrel.
The .17 doesn't have more power at the muzzle but because of its bullet it retains energy better than the .22 magnum. As the standard round for the US Military and NATO, it is much larger and powerful than the 22lr. caliber bullet being manufactured in the world today. While I don’t advocate using .22 LR for primary self protection unless a more effective caliber isn’t available or the user isn’t proficient with or, can handle one, I guarantee you I can empty a magazine from my Ruger 22/45’s, my Ruger 10/22s or any of other the other .22 LR firearms I have with deadly accuracy in seconds at self defense distances if need be. - Duration: 9:54. The .22WMR averages around 300-325 fpe with standard loadings.

While the 22lr is accurate and easy to shoot it does fail to penetrate adequately. Is a .22LR powerful enough to cycle the massive slide on a Desert Beag... Eagle? The .22 Super Maximum can be fired in any .22 LR gun in good conditions. CCW size.

So it truly comes all the way down to what you'd be utilising it for. This is a 22lr penetration test on wood. So JHP is useless and doesn’t penetrate as well as FMJ.
These include the Aguila Supermax (204 ft-lbs muzzle energy), CCI Stinger (191 ft-lbs muzzle energy), and CCI Velocitor (183 ft-lbs muzzle energy). Just curious, because I've heard about the incredible, and RARE conversions done. Surprisingly the bullets penetrated through a 2x4 and almost a giant piece if plywood.

The 22 Long Rifle is more powerful than the 22 Short. Your gun will not feed the Shorts.

It also has a longer case. Bullet weight and type.